DIRMC

A Database of Immunotherapy-Related Molecular Characteristics

Data Search

Through the search interface, you can either search according to the categories in the directory tree, or query by entering your keywords in the following search box. Information related to the selected keywords will be displayed in the results table below. Users can download the filtered target data by clicking the CSV button in the top right corner of the Result section.
You can enter any word you want to search, including, cancer, melanoma, MHC I, HLA-A*02:01, TRA, IGH, CD19, IL-2, etc. Please try as much as you want.
CATALOGUE
Cancer Name
Brain
Brain DIPG Meningioma Glioma Glioblastoma Chordoma Neuroblastoma Blastic Plasmacytoid Dendritic Cell Central Nervous System Neuroectodermal Peripheral Nerve Sheath Ependymoma Glio Chordoma Medulloblastoma Cns Primary Tumor Neuroendocrine Tumors
Headneck
Head And Neck Nasopharynx Oral Hnscc Nasopharyngeal Salivary Gland Hypopharynx Nasal Cavity Oropharynx Larynx Oropharyngeal Paranasal Sinus Pharyngeal Neck Retinoblastoma Laryngeal Eye Tongue Tonsillar
Thyroid
Thyroid
Gut
Gastroesophageal Esophagus ESCC Esophageal Digestive System Adenocarcinomas
Breast
Breast
Lung
Lung Nsclc Tracheal SCLC
Liver
Liver Hepatic Hepatocellular Hepatoma Hcc Heptocellular Biliary Bile Duct Ductal Hepatoblastoma Duct Cholangiocarcinoma
Stomach
Stomach Gastric Gastrointestinal Gej
Pancreas
Pancreas Pancreatic
Largeintestine
Colon Colorectal Anal Rectal Rectum Mcrc Small Intestinal Small Intestine Crc
Bladder
Bladder Urethral Ureter Urogenital Urothelial Genitourinary Upper Tract Urinary Urologic
Kidney
Kidney Renal Rcc
Male reproductive system
Prostate Scrotal Seminal Seminoma Prostatic Testis Male Reproductive System Genital Penis Testicular Penile
Female reproductive system
Cervix Ovarian Endometrioid Germ Cell Uterine Endometrial Female Reproductive System Cervical Ovaries Endometrium Ovary Vaginal Yolk Sac Fallopian Tube Vulvar
Bone
Bone Fibromyxoid
Blood
Blood Leukemia leukaemia Hematologic Cll Myeloproliferative AML CML NHL Myelodysplastic ALL
lymph
Lymphoma Lymphomas DLBCL B-Cell Hodgkin T-Cell B Cell Lymphoid
Skin and muscle
Skin Melanoma Epithelial Smooth Muscle Angiosarcoma Sarcoma Mesothelioma Peritoneal Epithelial Basal Cel Merkel cell Desmoid Tumor Mucoepidermoid Mucinous Mesothelin Rhabdoid Trophoblastic
Viral-associated cancers
HPV-Associated HPV-Related Ebv
Others
adrenocortical Small Cell Pediatric Cancer Solid Tumor Carcinoma Neoplasm Solid Cancer Malignant Ascites Neoantigen Anaplastic Oligoastrocytoma Carcinoma In Situ
Types of cancer immunotherapy
Non-specific immunotherapy Immune checkpoint inhibitors Cancer vaccines Adoptive cell therapies Targeted antibodies Oncolytic virus therapies
Gene
ACP3 CEACAM5 KLK3 AFP HAVCR2 MUC16 PCSK9 PDCD1 MS4A1 TNF IL17A IFNG CSF2 GZMB BTK PMEL CD274 CTLA4 LAG3 TNFRSF18 TNFRSF11A IL4 IL6 IL13 IL23A IDO1 CD40 CD70 TNFRSF4 CD47 VSIR BTLA ICOS TNFRSF9 BAG6 TIGIT CD276 IL2 IL2RA IL2RB IFNA1 IFNB1 TGFB1 IL7 IL10 IL15 IL18 IL21 IFNAR1 IFNAR2 CSF1R ERBB2 EGFR ERBB3 FGFR2 KDR PIK3CA PIK3CD PARP1 BRAF ALK KIT PDGFRA CTAG1A CD19 TNFRSF17 CD22 CLDN18 GPC3 CD4 TNFRSF8 MSLN CD52 CD38 TNFSF11 SLAMF7 CCR4 VEGFA CT83 CXCR4 STAT3 STING1 CD40LG CD80 ADORA2A CD28 TNFSF4 PDCD1LG2 PVR PVRIG SIRPA TPBG WT1 MAGEA12 TP53 KRAS BIRC5 TEP1 MET DLL1 IL3RA EPCAM FGFR1 KLRK1 CD33 CD5 MAGEC2 ARHGAP45 MAGEA3 MAGEA4 MAGEA8 MAGEA1 CTAG2 MAGEA10 GPRC5D PSCA FOLH1 MUC1 CLDN6 CLEC12A TLR7 TLR4 TLR3 TLR8 TLR9 TLR2 CD27 GEM KLRC1 CD37 DKK1 PSMB9 ANGPT1 B4GALNT1 ST3GAL5 IFNA2 CD3E ANGPT2 MAGEA2B DLL4 ansB NECTIN4 TNFRSF1A F3 TOP1
Target/Antigen(s)
IL-2Rβ IL-2 GM-CSF Toll-like receptor 7 T-cell Toll-like receptor 4 IFNAR1/IFNAR2 asparagine IFNAR1 Toll-like receptor 9 TNF-α IL-13 IL-15 CXCR4 IDO IL-2Rα Modified bacteria STAT3 IFN-α IFN-γ STING Toll-like receptor 8 Toll-like receptor 2 PD-1 PD-L1 CTLA-4 LAG-3 CTLA-4/PD-1 PD-1/PD-L1 CD47 41BB CD40 CD40L CD70 CD80 A2aR B7-H3 BTLA CD27 CD28 GITR ICOS KIR NKG2A OX40 OX40L PD-L2 PVR PVRIG SIRPα TIGIT TIM-3 VISTA VEGF PAP Modified bacteria Macrophage HPV-related antigens HBV Personalized neoantigens EGFR GM3 IFN-α2b+IFN-γ Tumor-associated antigens WT1 Ras MUC-1 PSA HER2 5T4 CEA MAGE antigens NY-ESO-1 Mesothelin P53 Survivin Telomerase GP100 AFP MAGE-A4 CEA, p53, HER-2/neu, MAGE2, MAGE3 CD19 BCMA CD19/CD22 Claudin 18.2 TIL Claudin 6 NKG2D CD33 CLL1 CIK EBV-related antigens CTL cytomegalo virus TGF-β GD2 NKT Tumor-specific antigens DC-CIK NK KK-LC-1 CD22 LMP2 HA-1 neoepitope CD38 LAGE-1a PSMA GPRC5D CD5 CD30 IL3RA GPC3 PSCA CDK4 MART1 UNC-CDK4-1 NY-ESO-1f Melan-A/MART-1 Melan-A A27L MelanA/MART1 Matrix protein (M1) MAGE-1 BAGE AKAP13-KLM APBB2-VQY-L7F BAIAP3-ILN C1S-9-N1H CHD8-KLN CHD8-KLN-P7A CHST14-MLM-F4L CLCN4-LLA-G8V CNKSR1-SLA-A9V DHX33-LLA DHX33-LLA-K5T DOCK7-FLN-M9L EXOC3L4-ILL EXOC3L4-ILL-V9I FNDC3B-VVL-L3M GALC-YVV-V3L GANAB-ALY-S5F HAUS3-ILN-T7A HTR1F-LVM-V2M ITIH6-RLG MAR11-9-F1L ME1-FLD-A8G MRM1-9 NSDHL-ILT-A9V OR1G1-FLF OR5M3-KMV OR5M3-KMV-T8N OR6F1-VLN OR6F1-VLN-T8M OR9Q2-SID-S1F PHKA2-LLS-SF PIGN-FLT-P7H PLXNB1-VLF-V1L PRSS16-LLL-L1Q PXDNL-SIL-S1F RYR3-VLN-E6K SEC24A-FLY-P5L SREBF1-YLQ-L6M ST6GALNAC2-LLF-Y6H TRPV4-FMI-A6T TRPV4-YLL TRPV4-YLL-A9T TTLL12-KLP-N7D VN1R2-LML-L3F VN1R5-MII-S7Y A2ML1-YLD-K7R AKAP13-KLM-Q8K ATP6AP1-KLG-G3W BAIAP3-ILN-V6I C15orf32-MLS-G9R CCM2-YML-R6H CD47-GLT-V6F CDC37L1-FLS-P6L DRAM1-FII-I3F ERBB2-ALI-H8Y HTR1F-10-V1M INTS1-VLL-L3F ITIH6-RLG-G3V KCNB2-LLA-P6T NOS1-FID-D3Y OR10A3-ILI-V6F OR14C36-FML-V6L OR2T1-FLN-F5L OR8B8-YVN-V2L PELP1-RLH-L7F PGM5-AVG-H5Y SH3RF2-HMV-MI SHROOM2-KLL-D6V SLC16A7-AMA-P6L SNX24-KLS-P6L TMEM195-ALS-S3L TRIM58-VLA-V1F TRPV3-LLL-A8V UNC13A-SQL-S1F USP28-LII-C5F WDR46-FLT-T3I ZDHHC7-SLL-P7L C1S-9 C3orf58-LMV DCHS1-TLF DOLPP1-GLM FLNA-HIA GOLGA3-SLD HTR1F-10 HTR1F-LVM IPO9-FSS KCNB2-LLA LCP1-NLF MLL2-ALS MRGPRF-RLW OR9Q2-FLF PELP1-RLH PHKA2-LLS PLXNB1-VLF PTCHD4-HQL RYR3-VLN SEC24A-FLY SLC15A2-ILG SLC2A4-ILI TBX3-GMG TRIM16-RMA TRPV3-LLL TRPV4-FMI TTLL12-KLP WDR46-FLT ZDHHC7-SLL IGF1-TMS-S4F DHX33-LLA-M4I HTR1F-9-V1M SLC1A2-YMS-S3P GABRG3-TAM-L5I APBB2-VQY IL17RA-FIT-TM TRPC1-MLL-Q5H TRIM16-RMA-R1T SMOX-KLA-KN TRIM58-VLA TBX3-GMG-T8M MRM1-9-T6P HERC1-SLL-PS BTBD1-FML-LI OVOL1-SLL-L9V HBZ-KLS BCL9L-FVY-T6I TRIM58-YMV-V3F KCNC3-FLP-A7V STOX1-RLM-M3I CELSR1-YLF-F3L KIF20B-YTS-S6L GCN1L1-9 C17orf75-ALS-V7A HBZ-KLS-A7T GABRG3-YVT-L7I CNKSR1-SLA NSDHL-ILT TEAD1-VLE AGXT2L2-ILT-M5I MLL2-ALS-L8H GOLGA3-SLD-P4L TEAD1-VLE-L8F SMARCD3-KLF-H8Y MPV17-YLW-A5P DCHS1-TLF-I5M GLRA1-LIF-F6L C3orf58-LMV-L4P LCP1-NLF-PL TEAD1-SVL-L9F SSPN-LMA-S8F COL18A1-VLL-S8F TPP2-SLA-WL HTR1F-9 GCN1L1-10 SSPN-9 SHROOM2-KLL HOXC9-YMY HAUS3-ILN VN1R2-LML OR10A3-ILI GPR174-FSF GLRA1-LIF HERC1-SLL KAT6A-KLS OR8D4-10 ZNF827-NLF APCDD1L-RLP FNDC3B-VVL SMOX-KLA OR8D4-9 SLC16A7-AMA BCL9L-FVY MYPN-RVI-R1L PIGN-FLT SCN3A-ALV ATP6AP1-KLG NOS1-FID CD47-GLT GABRG3-TAM PELP1-LVL ST6GALNAC2-LLF ERBB2-ALI ME1-FLD AKAP13 AKAP13-Q8K COL18A1 FNDC3B FNDC3B-L3M GANAB MLL2 MRM1 NSDHL NSDHL-A9V PGM5 PGM5-H5Y SEC24A SMARCD3 SNX24 TEAD1-(SVL) TEAD1-(VLE) WDR46 ERBB2-H8Y GANAB-S5F GCN1L1-L6P GNL3L-R4C MAGEA6-KVAK MLL2-L8H SEC24A-P5L SMARCD3-H8Y SNX24-P6L USP28-C5F WDR46-T3I MAGEA3-KVAE USP28 ERBB2 MRM1-T6P TEAD1-L9F TEAD1-L8F PABPC1-R5Q HCV-L2I CMV-MLN HCV-LLF HCV-YLL IVPA-FMY ALADH-VLM HCV-A9N TYR-YMD DRIP-MLY PP1-SII ZNT8-LLI ZNT8-VVT IGRP-FLW AGL-GLI ZNT8-VMI DDX5-YLL ZNT8-LLS GFAP-NLA HCHGA-TLS MAGEC2-LLF IGRP-VLF CD1-LLG SNPG-IML PPI-RLL GLNS-GLL PPI-15-23 PD5-KLS HCV-K1Y CLCN4-LLA VN1R5-MII PXDNL-SIL LTAg PRELP NEB ETNK-1 ETNK-2 TR10BP FAM58A-1 FAM58A-2 FAM58A-3 CD20 CD52 RANKL SLAMF7 CCR4 VEGF/VEGF-R CD19 x CD3 EGFR x cMet CD20 x CD3 PDGFRα BCMA x CD3 CD123 EpCAM DNA topoisomerase 1 TNF-R1 Tissue factor Nectin-4 IL-2Rα x IL-2Rβ CA-125 DLL4 x VEGF Angiopoietin ANG2 CD20 x CD3|CD22 x CD28 CD37 cMet DLL FGF-R DKK1 Ang2 x VEGF VEGF-R CSF1R Herpes simplex virus Adenovirus ECHO-7 Vaccinia virus Coxsackie virus Maraba virus Newcastle Disease Virus Measles Reovirus Vesicular stomatitis virus
Approved organization
CECMED EMA FDA HealthCanada Latvia NMPA PEI PMDA RMH
Phase in ClinicalTrials
Early Phase 1 No longer available Not Applicable Phase 1 Phase 1|Phase 2 Phase 1a|1b Phase 1b Phase 2 Phase 2|Phase 3 Phase 3 Phase 4
MHC_class
MHCI
HLA-A*02:01 HLA-A*02 HLA-A*02:01:48 HLA-A*02:01:59 HLA-B*35:01 HLA-Cw*16:01
MHCII
HLA-DRB1*04-01
Locus
IGH TRA TRB TRA-TRB
Result
Found: 0
Total:
CSV
CopyRight © Center for Bioinformatics, Harbin Institute of Technology, China.